High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer

E Brain; C Levy; D Serin; H Roché; M Spielmann; R Delva; C Veyret; L Mauriac; M Rios; A L Martin; M Jimenez; B Asselain; M Gauthier; F Bonnetain; P Fumoleau

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High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer

机译：血液学外毒性反应的高发生率损害了乳腺癌的剂量密集型序贯辅助化疗

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Background:A dose-dense strategy has been considered to improve results of adjuvant chemotherapy for breast cancer. This randomised phase II trial investigated the feasibility of this approach with sequential anthracyclines and taxanes-based chemotherapy.

机译：背景：已考虑采用剂量密集策略来改善乳腺癌辅助化疗的效果。这项随机的II期临床试验研究了采用顺序蒽环类药物和紫杉烷类化疗的方法的可行性。

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《British Journal of Cancer》 |2011年第10期|共7页
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E Brain; C Levy; D Serin; H Roché; M Spielmann; R Delva; C Veyret; L Mauriac; M Rios; A L Martin; M Jimenez; B Asselain; M Gauthier; F Bonnetain; P Fumoleau;
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中图分类肿瘤学;
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1. High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer [J] . E Brain, C Levy, D Serin, British Journal of Cancer . 2011,第10期

机译：血液学外毒性反应的高发生率损害了乳腺癌的剂量密集型序贯辅助化疗
2. Long-term efficiency and toxicity of adjuvant dose-dense sequential adriamycin-Paclitaxel-cyclophosphamide chemotherapy in high-risk breast cancer. [J] . Kelemen G, Uhercsak G, Ormandi K, Oncology: International Journal of Cancer Research and Treatment . 2010,第3a4期

机译：辅助剂量密集的序贯阿霉素-紫杉醇-环磷酰胺化疗在高危乳腺癌中的长期疗效和毒性。
3. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leu [J] . Citron ML, Berry DA, Cirrincione C, Journal of Clinical Oncology . 2003,第8期

机译：剂量密集，常规，序贯和同期联合化疗作为淋巴结阳性原发性乳腺癌的术后辅助治疗的随机试验：C9741 / Cancer and Leu组间试验的首次报道
4. Determining the importance of parameters extracted from multi-parametric MRI in the early prediction of the response to neo-adjuvant chemotherapy in breast cancer [C] . Amirhessam Tahmassebi, Katja Pinker-Domenig, Georg Wengert, SPIE Medical Imaging Conference . 2018

机译：确定从多参数MRI提取的参数在乳腺癌新辅助化疗反应的早期预测中的重要性
5. The Effects of Adjuvant Chemotherapy on Brain Function in Breast Cancer Patients and a Cancer-Chemotherapy Rodent Model. [D] . Barr, Alicia Thomas. 2014

机译：辅助化疗对乳腺癌患者脑功能的影响和癌症化学疗法的啮齿动物模型。
6. High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer [O] . E Brain, C Levy, D Serin, 2011

机译：血液学外毒性的高发生率损害了乳腺癌的剂量密集型序贯辅助化疗
7. Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial [O] . George Fountzilas, Urania Dafni, Christos Papadimitriou, 2014

机译：如所示，在早期乳腺癌患者中进行了剂量密集的序贯辅助化疗，随后是曲妥珠单抗治疗了一年：希腊合作肿瘤小组随机III期临床试验的5年中位随访首次报道

High rate of extra-haematological toxicity compromises dose-dense sequential adjuvant chemotherapy for breast cancer

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