Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck

J M del Campo; R Hitt; P Sebastian; C Carracedo; D Lokanatha; J Bourhis; S Temam; D Cupissol; D De Raucourt; N Maroudias; C M Nutting; N Compton; D Midwinter; L Downie; N Biswas-Baldwin; I El-Hariry; K J Harrington

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Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck

机译：拉帕替尼单药治疗的效果：未经治疗的初次接受治疗的头颈部局部局部鳞状细胞癌患者的II期随机研究结果

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Background:Lapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and human EGFR-2 (HER-2) tyrosine kinases. This study investigated the pharmacodynamic and clinical effects of lapatinib in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN).

机译：背景：拉帕替尼是表皮生长因子受体（EGFR）和人EGFR-2（HER-2）酪氨酸激酶的双重抑制剂。这项研究调查了拉帕替尼在局部晚期头颈部鳞状细胞癌（SCCHN）患者中的药效学和临床效果。

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《British Journal of Cancer》 |2011年第5期|共10页
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J M del Campo; R Hitt; P Sebastian; C Carracedo; D Lokanatha; J Bourhis; S Temam; D Cupissol; D De Raucourt; N Maroudias; C M Nutting; N Compton; D Midwinter; L Downie; N Biswas-Baldwin; I El-Hariry; K J Harrington;
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中图分类肿瘤学;
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1. Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: Rationale for future randomised trials in human papilloma virus-negative disease [J] . HarringtonK., BerrierA., RobinsonM., European journal of cancer: official journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR) . 2013,第7期

机译：口服拉帕替尼联合放化疗联合治疗晚期头颈部鳞状细胞癌的随机II期研究：人类乳头瘤病毒阴性疾病未来随机试验的依据
2. Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study [J] . Harrington Kevin, Temam Stephane, Mehanna Hisham, Journal of Clinical Oncology . 2015,第35期

机译：高风险患者头颈部鳞状细胞癌切除术后术后辅助用拉帕替尼和同期放化疗联合维持拉帕替尼单药治疗：III期，随机，双盲，安慰剂对照研究
3. Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck. [J] . Harrington KJ, El-Hariry IA, Holford CS, Journal of Clinical Oncology . 2009,第7期

机译：拉帕替尼联合化学放疗在头颈部局部晚期鳞状细胞癌患者中进行的I期研究。
4. CCND1 as a Predictive Biomarker of Neoadjuvant Chemotherapy in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma [C] . Zhien Feng, Lizhen Wang, Bingshun Wang, Academic Committee Conference of Shanghai key lab of stomatology . 2011

机译：CCND1作为局部晚期头颈部鳞状细胞癌患者新辅助化疗的预测生物标志物
5. EGFRvIII Expression and Signaling in head and neck squamous cell carcinoma. [D] . Wheeler, Sarah E. 2012

机译：EGFRvIII在头颈部鳞状细胞癌中的表达和信号传导。
6. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck [O] . J M del Campo, R Hitt, P Sebastian, 2011

机译：拉帕替尼单药治疗的效果：未经治疗的初次治疗的头颈部局部局部鳞状细胞癌患者的随机II期研究结果
7. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck [O] . J M del Campo, R Hitt, P Sebastian, 2011

机译：Lapatinib单疗法的影响：治疗幼稚患者的随机期II研究结果 - 颈部局部晚期鳞状细胞癌

Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck

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