A Facile Synthetic Protocol for the Preparation of 4-Halobutyl Benzoates via Carbon-Oxygen Bond Cleavage of THF

摘要

A facile synthetic route for the preparation of 4-halobutyl benzoates has been developed. 4-Chloro-, bromo-and iodobutyl benzoates can be easily prepared from the reaction of benzoyl chloride and metal halides in THF under extremely mild conditions. 4-Halo groups were easily controlled by selecting suitable metal halides.