Syntheses of Phosphonamides Containing Aminobenzylphosphonic Acid and Aminopenicillanic Acid

摘要

This paper reports new phosphonamide derivatives which contain diethyl aminomethylphosphonate, diethyl DL-1-aminobenzylphosphonate and 6-aminopenicillanic acid; N-(ethyl phthalimidomethylphosphonyl)-L-methionine methyl ester, N-(ethyl phthalimidomethylphosphonyl)-L-valine ethyl ester, N-[Eethyl N-(methoxycarbonylmethyl)benzylphosphonamido] -2-phthalimidoacetamide, N-[ethyl N-(diethyl phosphonylbenzyl)methylphthalamido] phthalimide, N-[ethyl {ethyl N-(diethyl phosphonylbenzyl)aminomethylphosphonamido} phosphonylmethyl] phthalimide, N-[ethyl N-(diethyl phosphonylbenzyl)methylphosphonamido]-2-phthali midoacetamide, N, N`-bis (ethyl phthalimidomethylphosphonyl)ethylene diamine, 6-(ethyl DL-1-aminobenzylphosphonamido) penicillanic acid, ethyl N-(ethoxycarbonylmethyl)-1-aminobenzylphosphon amide, ethyl N-(diethyl phosphonylbenzyl)aminomethylphosphonamide and N,N`-bis (ethyl aminomethylphosphonyl) ethylene diamine.