Synthesis of 4, 5, 6, 7-Tetraphenyl-8-(substituted)-3 (2H)-phthalazinone Derivatives Likely to Posses Antihypertensive Activity

摘要

The interaction of tetraphenylphthalic anhydride with o-chlorotoluene under Friedel-Craft condition gives 2-(4-chloro-3-methyl)benzoyl-3,4,5,6-tetraphenyl benzoic acid(1), which on reaction with hydrazine derivatives gave phthalazinones (2a-d). The behaviour of (2a) towards carbon electrophiles and carbon nucleophiles has been investigated. The chlorophthalazinones (4a) also has been synthesized from the action of PCl5/POCl3 on (2a). The behaviour of (4a) towards nitrogen, and oxygen nucleophiles also have been described.