The physical status of humans can be estimated by observing the appearance of the tongue coating, known as tongue diagnosis. The goals of this study were to reveal the relationship between tongue coating appearance and the oral microbiota in patients with gastric cancer and to open a novel research direction supporting tongue diagnosis. We used a tongue manifestation acquisition instrument to analyse the thickness of the tongue coating of patients with gastric cancer and that of healthy controls, and high-throughput sequencing was used to describe the microbial community of the tongue coating by sequencing the V2–V4 region of the 16S rDNA. The tongue coatings of 74 patients with gastric cancer were significantly thicker than those of 72 healthy controls (343.11 ± 198.22 versus 98.42 ± 48.25,P<0.001); 51.35% of the patients were assessed as having thick tongue coatings, whereas all healthy controls were assessed as having thin tongue coatings. Thick tongue coatings presented lower microbial community diversity than thin tongue coatings. The tongue coating bacterial community is associated with the appearance of the tongue coating. The tongue coating may be a potential source for diagnosing gastric cancer, but its sensitivity needs to be further improved.
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机译:可以通过观察舌苔的外观来估计人的身体状况,这称为舌诊。这项研究的目的是揭示胃癌患者舌苔外观与口腔菌群之间的关系,并为支持舌诊打开新的研究方向。我们使用舌头表现获取仪器来分析胃癌患者和健康对照者的舌苔厚度,并使用高通量测序通过对舌苔的V2-V4区域进行测序来描述舌苔的微生物群落。 16S rDNA。 74名胃癌患者的舌苔明显厚于72名健康对照者的舌苔(343.11±198.22 vs 98.42±48.25,P <0.001); 51.35%的患者被评估为舌苔厚,而所有健康对照者被评估为舌苔薄。厚舌苔比薄舌苔具有较低的微生物群落多样性。舌苔细菌群落与舌苔的外观有关。舌苔可能是诊断胃癌的潜在来源,但其敏感性需要进一步提高。
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