THE RELATIONSHIP BETWEEN VITAMIN D, CLINICAL OUTCOMES AND MORTALITY RATE IN ICU PATIENTS: A PROSPECTIVE OBSERVATIONAL STUDY

摘要

Background: According to the high prevalence of Vitamin D deficiency, a few studies have been conducted to clarify the relationship between 25-hydroxyvitamin D (25 (OH) D) and clinical outcomes in critically ill patients. The objective of this study was to determine this probable association. Materials and Methods: Serum 25 (OH) D, C-reactive protein, malnutrition measurements, and Intensive Care Unit (ICU) -acquired infection from 185 patients in ICU were assessed in the first 24 h of admission and they were followed for the other outcomes.Results: About 93.5% of patients were classified as deficient and insufficient while the others were categorized in sufficient group.25 (OH) D status was not significantly associated with mortality rate (P=0.66), and no significant differences in ventilation time were observed (P=0.97). Sufficient group left the ICU sooner, but the difference was not significant (P=0.75). Besides the results of relationship between 25 (OH) D concentration and nutritional status (P=0.69) were not significant. In addition, sufficient group suffered from infection more than insufficient patients, but this relationship was not significant (P=0.11).Conclusion: In this study, we found that 25 (OH) D insufficiency is common in ICU patients, but no significant association between low 25 (OH) D levels and ICU outcomes were observed. Hence, because of vital roles of Vitamin D in human’s body, comprehensive study should conduct to determine the decisive results.