Acute myeloid leukaemia with haemophagocytic lymphohistiocytosis presenting as cholestatic Jaundice

摘要

Haemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disease of normal but overactive histiocytes and lymphocytes characterised by fever, cytopenias, and hepatosplenomegaly with haemophagocytosis. It is traditionally classified as familial/primary HLH which occurs due to genetic abnormalities and secondary HLH which is associated with infections, autoimmune diseases, immune deficiencies, metabolic diseases, drugs, or malignancies, without an identifiable genetic abnormality. Haematological malignancy associated HLH is mostly accompanied by lymphoid neoplasms. The present study reports a rare case of this syndrome in combination with acute myeloid leukaemia with an even rarer presentation of cholestatic jaundice.