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首页> 外文期刊>Jundishapur Scientific Medical Journal >??? ????? ???????? ???? ? ???? ????? ?? ????? ???????? SERCA2a ? ????????? ?? ????? ????????? ? ?????????? ??????? ?????? ?? ???? ??????

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??? ????? ???????? ???? ? ???? ????? ?? ????? ???????? SERCA2a ? ????????? ?? ????? ????????? ? ?????????? ??????? ?????? ?? ???? ??????

机译：??? ?????? ????????? ???? ？ ???? ?????? ?? ?????? ????????? SERCA2a？ ????????? ?? ?????? ????????? ？ ?????????? ??????? ?????? ?? ???? ??????

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????? ? ???: ????? ????? ????? ???????? ?? ???? ??? ???? ??????-?????? ?? ??? ???? ??-????. ???????? ??? ?? ????? ???? ????? ?????? SERCA2a? ????-???? ??????-????? ?????? ? PLN ? ??????? ????? ??? ?? ????? ????? ???. ??? ?????: 18 ??? ?????? ?? ???? ???? ?????? ?? ?? ???? ????? ????? ?????(AET)? ????? ???????? ????(HIIT)? ? ?????(CO) ???? ??????. ???? AET ? HIIT ?? ????? ?? ????-???? 12 ?? 15? ? 25 ?? 30 ? 5 ??? ?? ???? ? ?? ??? 8 ???? ?? ??? ?????? ??????. ?? ????? ???? ???????? ???? ???????(EDL) ? ???? ????(Sol) ???? ?? ? ????? ???????-??? SERCA2a ? PLN ?? ??????? ?? ??? ?????? ??????-???? ??. ????? ?????? ??????? ?? ????? ????? t ??????? ?????? ? ????? ?????? ??????? ?????? ?? ??? ????-???? (05/0α=) ???? ????? ????? ??????? ?????. ????? -??: ?? ???????? ???????? SERCA2a ??? ????? EDL ? SOL ???? ?????(001/0=p) ? ???? AET (030/0=p) ????? ????-???? ???? ????. ??? ????? ????? ???????? PLN ??? ????? EDL ? SOL ???? ?? ???? AET ????-???? ???(007/0=p). ??-?????? ??? ????-??? ?????? AET ? HIIT ?? ??? ????? SERCA2a (046/0= p) ? PLN (006/0= p)?????? ????-??? ???. ??????? ??? ???-????? ? ??? ??? ?????? ?? ????? ???????? SERCA2a (042/0= p ) ? ????? ???????? PLN (008/0=P) ??? ?????? ????-???? ?????? ?????. ?????- ????: ???? ??????? ?? ?????? ????? ??????? ??-???? ????? ???? ?? ?????? ?????? ?? ??? ????? ?????? ??? ??? ?????? ? ??? ????? ?????? ?? ?? ???????.

机译：?????? ？ ???：????? ?????? ?????? ????????? ?? ???? ??? ???? ??????-?????? ?? ??? ???? ??-????。 ????????? ??? ?? ?????? ???? ?????? ?????? SERCA2a？ ????-???? ??????-????? ?????? ？ PLN？ ??????? ?????? ??? ?? ?????? ?????? ???。 ??? ?????：18 ??? ?????? ?? ???? ???? ?????? ?? ?? ???? ?????? ?????? ??????（AET）？ ?????? ????????? （HIIT）？？ ??????（CO）???? ?????? ???? AET？ HIIT ?? ?????? ?? ????-???? 12 ?? 15吗？ 25 ?? 30？ 5 ??? ?? ???? ？ ?? ??? 8 ???? ?? ??? ?????? ?????? ?? ?????? ???? ????????? ???? ???????（EDL）？ ???? ????（Sol）???? ?? ？ ?????? ???????-??? SERCA2a？ PLN ?? ??????? ?? ??? ?????? ??????-???? ??。 ?????? ?????? ??????? ?? ?????? ?????? t ??????? ?????? ？ ?????? ?????? ??????? ?????? ?? ??? ????-???? （05 /0α=）???? ?????? ?????? ??????? ?????? ?????? -??：?? ????????? ????????? SERCA2a ??? ?????? EDL？ SOL ???? ??????（001/0 = p）？ ???? AET（030/0 = p）????? ????-???? ???? ????。 ??? ?????? ?????? ????????? PLN ??? ?????? EDL？ SOL ???? ?? ???? AET ????-???? （007/0 ＝ p）。 ??-?????? ??? ????-??? ?????? AET？ HIIT ?? ??? ?????? SERCA2a（046/0 = p）？ PLN（006/0 = p）?????? ????-??? ???。 ??????? ??? ???-?????? ？ ??? ??? ?????? ?? ?????? ????????? SERCA2a（042/0 = p）？ ?????? ????????? PLN（008/0 = P）??? ?????? ????-???? ?????? ?????? ?????-????：???? ??????? ?? ?????? ?????? ??????? ??-???? ?????? ???? ?? ?????? ?????? ?? ??? ?????? ?????? ??? ??? ?????? ？ ??? ?????? ?????? ?? ?? ???????。

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《Jundishapur Scientific Medical Journal 》 |2018年第3期| 共14页
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??????? ???????????? ?????? ?.?.? ?? ???? ??????????? (SERCA2a )????? ???????? ??? ????????? ????? ?????;

机译：??????? ???????????? ?????? ？。？。？ ?? ???? ???????????? （SERCA2a）????? ????????? ??? ????????? ?????? ??????;

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1. Effect of intracoronary administration of AAV1 AAV1 / SERCA2a SERCA2a on ventricular remodelling in patients with advanced systolic heart failure: results from the AGENT‐HF AGENT‐HF randomized phase 2 trial [J] . Hulot Jean‐Sébastien, Salem Joe‐Elie, Redheuil Alban, European journal of heart failure: journal of the Working Group on Heart Failure of the European Society of Cardiology . 2017 ,第11期

机译：AAV1 AAV1 / SERCA2A SERCA2A宫内施用对晚期收缩性心力衰竭患者心室重塑的影响：试剂-HF试剂-HF随机阶段2试验的结果
2. Is reduced SERCA2a expression detrimental or beneficial to postischemic cardiac function and injury? Evidence from heterozygous SERCA2a knockout mice [J] . M. A. Hassan Talukder, Anuradha Kalyanasundaram, Li Zuo, American Journal of Physiology . 2008 ,第3aPta2期

机译：降低的SERCA2a表达对缺血后心脏功能和损伤有害还是有益？来自杂合SERCA2a基因敲除小鼠的证据
3. Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure [J] . B M Mayosi, A Kardos, C H Davies, Heart . 2006 ,第1期

机译：SERCA2a的杂合破坏与人类心脏功能的损害无关：对SERCA2a作为心力衰竭的治疗靶标的意义
4. Hsp70 protects against peroxynitrite-induced inactivation of SERCA2a by preventing protein oxidation and aggregation. [D] . Vigna, Christopher. 2009

机译：Hsp70通过防止蛋白质氧化和聚集，防止过亚硝酸盐诱导的SERCA2a失活。
5. Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure [O] . B M Mayosi, A Kardos, C H Davies, 2006

机译：SERCA2a的杂合破坏与人类心脏功能的损害无关：对SERCA2a作为心力衰竭的治疗靶标的意义
6. Heterozygous disruption of SERCA2a is not associated with impairment of cardiac performance in humans: implications for SERCA2a as a therapeutic target in heart failure. [O] . Mayosi, BM, Kardos, A, Davies, CH, 2006

机译：SERCA2a的杂合破坏与人类心脏功能的损害无关：对SERCA2a作为心力衰竭的治疗靶标的意义。

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