Physico-chemical study of new ruthenium(III), Pd(II) and Co(II) complexes, DNA binding of Pd(II) complex and biological applications

摘要

New series of ruthenium(III), Pd(II) and Co(II) complexes of thiosemicarbazone ligands were prepared and characterized. It has been inferred method of bonding and general geometry of the complexes through FTIR, UV–Vis, 1 H NMR spectroscopic studies, molar conductivity, magnetic, thermal and elemental analysis. On the basis of the above studies, it has suggested that the tetrahedral geometry for Ru(III), Co(II) complexes and square planar geometry for Pd(II)complex. Fluorescence binding of palladium complex(4) with DNA molecules showed no fluorescence quenching capability when compared with the complex(4) as a quencher. Also the ligand and complexes have been tested for their inhibitory effect on the growth of bacteria: Streptococcus pyogenes as Gram positive bacteria and Escherichia coli as Gram-negative bacteria. The activity data exhibit that most of the tested ligand and metal complexes reveal that remarkable antibacterial activity against these organisms. Highlights ? Ruthenium(III), Pd(II) and Co(II) complexes have been synthesized and characterized. ? Analytical, spectral and thermal data confirm the structure of the compounds. ? DNA binding of Pd(II) complex and antibacterial activity have been investigated.