Effect of the Inclusion Nanocomplex Formed of Titanium Tetrafluoride and β-Cyclodextrin on Enamel Remineralization

摘要

Objective: Titanium tetrafluoride (TiF₄) is a topical agent used in the control of dental caries; however, it is highly acidic. To minimize this effect, cyclodextrins (CDs) are used. This study evaluated the in vitro potential of TiF₄ and β-CD on remineralization. Methods: Forty bovine enamel blocks were selected by microhardness and randomly assigned to four groups ( n = 10 per group): control (distilled and deionized water), 1% β-CD solution, 1% TiF₄ solution, and TiF₄: β-CD solution. The blocks were subjected to a pH cycling regimen for 8 days. After that, samples were evaluated by cross-sectional microhardness (CSMH), scanning electron microscopy (SEM), and energy dispersive spectrometry (EDS). Data were assessed for normality and analyzed using ANOVA and Tukey's tests (α = 0.05). Results: Regarding CSMH, TiF₄: β-CD was statistically superior to the control ( P = 0.033), β-CD ( P = 0.022), and TiF₄ ( P = 0.006). SEM photomicrography revealed the titanium dioxide coating on slabs treated with TiF₄ and TiF₄: β-CD. EDS assessment demonstrated the presence of titanium on the surface of slabs treated with TiF₄ and TiF₄: β-CD. Conclusion: The solution containing the inclusion nanocomplex formed of TiF₄ and β-CD was able to reharden the enamel subsurface. K EYWORDS : Beta-cyclodextrins , dental caries , fluoride , microhardness , tooth remineralization