Genotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population

摘要

BackgroundGenotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects. MethodsWe analyzed 10 genotype frequencies for following polymorphisms associated with the development of CINV: serotonin 5-HT₃ receptors (HTR3); neurokinin-1 receptors (Tachykinin-1 receptors, TACR1); dopamine D₂ receptors (DRD2); and catechol-O-methyltransferase (COMT). ResultsAll polymorphisms were successfully genotyped in 200 Japanese subjects and were in Hardy-Weinberg equilibrium. Almost all genotype frequencies were similar to those in the HapMap database or in the previous reports, while frequencies for the Y192H polymorphism in TACR1 were different in Japanese subjects from those in a previous report. ConclusionsThe present study revealed genotype frequencies for polymorphisms, which were related to the appearance of CINV in Japanese subjects. Individual therapy based on genotype variations for each race is needed to allow cancer patients to undergo chemotherapy more safely and to understand etiology of CINV.