首页> 外文期刊>Journal of Osteoporosis >Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats
【24h】

Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

机译:维生素E对去卵巢大鼠骨骼生物力学和组织形态学参数的影响

获取原文
           

摘要

The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n=12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD of vitamin E had increased serum alkaline phosphatase compared to the Ovx-control group. Bone histomorphometry analysis indicated a decrease in bone resorption as well as increased bone formation and mineralization in the Ovx groups supplemented with MD and HD of vitamin E. Microcomputed tomography findings indicated no effects of vitamin E on trabecular bone of fifth lumbar vertebrae. Animals receiving HD of vitamin E had enhanced fourth lumbar vertebra quality as evidenced by improved ultimate and yield load and stress when compared to Ovx-control group. These findings demonstrate that vitamin E improves bone quality, attenuates bone resorption, and enhances the rate of bone formation while being unable to restore bone density and trabecular bone structure.
机译:本研究检查了在切除卵巢的(Ovx)大鼠中维生素E逆转骨丢失的剂量依赖性作用。对Sprague-Dawley大鼠进行假手术(Sham)或Ovx,并给予对照饮食120天以使其失去骨骼。随后,将大鼠分为5组(n = 12 /组):假手术,Ovx对照,低剂量(Ovx +300μmg/ kg饮食; LD),中剂量(Ovx +525μmg/ kg饮食; MD),和高剂量(Ovx + 750 mg / kg饮食; HD),并在100天后牺牲。与Ovx对照组相比,接受维生素E的MD和HD的动物的血清碱性磷酸酶升高。骨组织形态计量学分析表明,补充MD和HD维生素E的Ovx组骨吸收减少,并且骨骼形成和矿化增加。微计算机断层扫描结果表明,维生素E对第五个腰椎小梁骨没有影响。与Ovx对照组相比,接受维生素E HD的动物的第四腰椎质量增强,这通过改善的最终和屈服负荷以及压力来证明。这些发现表明,维生素E改善了骨质,减弱了骨吸收,并提高了骨形成速率,同时又无法恢复骨密度和小梁骨结构。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号