An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

Jeremy R. Johnson; Dominique Lossignol; Mary Burnell-Nugent; Marie T. Fallon

首页> 外文期刊>Journal of pain and symptom management. >An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

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An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

机译：一项开放标签扩展研究，用于研究终末期癌症相关的难治性阿片类镇痛药患者的THC / CBD口腔黏膜喷雾剂和口腔黏膜THC喷雾剂的长期安全性和耐受性

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ContextChronic pain in patients with advanced cancer poses a serious clinical challenge. The Δ9-tetrahydrocannabinol (THC)/cannabidiol (CBD) oromucosal spray (U.S. Adopted Name, nabiximols; Sativex?) is a novel cannabinoid formulation currently underg

机译：晚期癌症患者的慢性疼痛带来了严重的临床挑战。 Δ9-四氢大麻酚（THC）/大麻二酚（CBD）口腔粘膜喷雾剂（美国采用名称，萘比莫斯; Sativex？）是目前正在研究的新型大麻素制剂

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《Journal of pain and symptom management.》 |2013年第2期|共12页
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Jeremy R. Johnson; Dominique Lossignol; Mary Burnell-Nugent; Marie T. Fallon;
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1. An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics [J] . JohnsonJ.R., LossignolD., Burnell-NugentM., Journal of pain and symptom management. . 2013,第2期

机译：开放性扩展研究旨在研究THC / CBD口腔粘膜喷雾剂和口腔粘膜THC喷雾剂在晚期癌症相关疼痛至强阿片类镇痛药难以治疗的患者中的长期安全性和耐受性
2. Effectiveness and tolerability of THC:CBD oromucosal spray as add-on measure in patients with severe chronic pain: analysis of 12-week open-label real-world data provided by the German Pain e-Registry [J] . Michael A Ueberall, Ute Essner, Gerhard HH Mueller-Schwefe Journal of Pain Research . 2019,第2期

机译：THC：CBD口腔粘膜喷雾剂作为重度慢性疼痛患者的附加措施的有效性和耐受性：由德国疼痛电子注册中心提供的为期12周的开放标签真实世界数据分析
3. A multicentre, open-label, follow-on study to assess the long-term maintenance of effect, tolerance and safety of THC/CBD oromucosal spray in the management of neuropathic pain [J] . Hoggart B., Ratcliffe S., Ehler E., Journal of neurology . 2015,第1期

机译：一项多中心，开放标签的后续研究，旨在评估THC / CBD口腔粘膜喷雾剂在神经性疼痛管理中的作用，耐受性和安全性的长期维持
4. Effectiveness and tolerability of THC:CBD oromucosal spray as add-on measure in patients with severe chronic pain: analysis of 12-week open-label real-world data provided by the German Pain e-Registry [O] . Michael A Ueberall, Ute Essner, Gerhard HH Mueller-Schwefe 2019

机译：THC：CBD口腔粘膜喷雾剂作为重度慢性疼痛患者的附加措施的有效性和耐受性：德国疼痛电子注册中心提供的为期12周的标签公开真实世界数据分析
5. A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers [O] . Colin Stott, Linda White, Stephen Wright, 2013

机译：在三个平行组中进行的一项I期，开放标签，随机交叉研究，以评估利福平，酮康唑和奥美拉唑对健康志愿者THC / CBD口腔粘膜喷雾剂药代动力学的影响

An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

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