Can a Controlled-Release Oral Dose Form of Oxycodone Be Used as Readily as an Immediate-Release Form for the Purpose of Titrating to Stable Pain Control?

Robert T. Salzman; Michael S. Roberts; James Wild; Carol Fabian; Robert F. Reder; Paul D. Goldenheim

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Can a Controlled-Release Oral Dose Form of Oxycodone Be Used as Readily as an Immediate-Release Form for the Purpose of Titrating to Stable Pain Control?

机译：为了滴定达到稳定的疼痛控制目的，羟考酮的控制释放口服剂量形式是否可以立即用作立即释放形式？

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Two separate trials compared controlled-release (CR) oral oxycodone (administered every 12 hours) with immediate-release (IR) oxycodone (4 times a day) to determine whether patients with chronic pain could be titrated to stable pain control as readily wit

机译：两项单独的试验比较了控释（CR）口服羟考酮（每12小时给药一次）与速释（IR）羟考酮（每天4次），以确定慢性疼痛患者是否可以轻易地调整为稳定的疼痛控制剂

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《Journal of pain and symptom management.》 |1999年第4期|共9页
作者
Robert T. Salzman; Michael S. Roberts; James Wild; Carol Fabian; Robert F. Reder; Paul D. Goldenheim;
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1. Can a controlled-release oral dose form of oxycodone be used as readily as an immediate-release form for the purpose of titrating to stable pain control? [J] . Salzman RT, Roberts MS, Wild J, Journal of pain and symptom management. . 1999,第4期

机译：为了滴定达到稳定的疼痛控制目的，羟考酮的控释口服剂型是否可以立即用作速释形式？
2. Pharmacokinetic comparison of controlled-release and immediate-release oral formulations of simvastatin in healthy Korean subjects: a randomized, open-label, parallel-group, single- and multiple-dose study. [J] . Jang SB, Lee YJ, Lim L Clinical therapeutics . 2010,第1期

机译：辛伐他汀控释和速释口服制剂在健康韩国受试者中的药代动力学比较：一项随机，开放标签，平行组，单剂量和多剂量研究。
3. Pharmacokinetic comparison of controlled-release and immediate-release oral formulations of simvastatin in healthy Korean subjects: a randomized, open-label, parallel-group, single- and multiple-dose study. [J] . Jang SB, Lee YJ, Lim L Clinical therapeutics . 2010,第1期

机译：辛伐他汀控释和速释口服制剂在健康韩国受试者中的药代动力学比较：一项随机，开放标签，平行组，单剂量和多剂量研究。
4. Lack of Dose Flexibility in Solid Oral Controlled-Release Dosage Forms [C] . G.A. Green, C. Berg, N. Valdez Annual meeting exposition of the Controlled Release Society . 2009

机译：口服控制释放剂量形式的剂量灵活性不足
5. Abuse liability of controlled-release oxycodone formulations. [D] . Rafat, Bijan. 2016

机译：控释羟考酮制剂的滥用责任。
6. A comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients [O] . Krzysztof Nosek, Wojciech Leppert, Hanna Nosek, 2017

机译：口服控释吗啡和羟考酮与丁丙诺啡和芬太尼透皮制剂治疗癌症严重疼痛的比较
7. A comparison of oral controlled-release morphine and oxycodone with transdermal formulations of buprenorphine and fentanyl in the treatment of severe pain in cancer patients [O] . Krzysztof Nosek, Wojciech Leppert, Hanna Nosek, 2017

机译：口腔控制释放吗啡和羟考酮与丁丙诺啡和芬太尼的透皮制剂治疗严重疼痛治疗癌症患者

Can a Controlled-Release Oral Dose Form of Oxycodone Be Used as Readily as an Immediate-Release Form for the Purpose of Titrating to Stable Pain Control?

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