Effects of Granulocyte Colony-Stimulating Factor (GCSF) on Persistent Thin Endometrium in Frozen Embryo Transfer (FET) Cycles

摘要

Objective To predict the effectiveness of granulocyte colony-stimulating factor (GCSF) in the treatment of persistent thin endometrium resistant to other treatments in frozen embryo transfer (FET) cycles. Study Design This is a hospital-based prospective study. Patients Thirty-five women with persistent thin endometrium ( Intervention(s) Intrauterine infusion of GCSF (300?mcg/1?ml) was done in patients with thin endometrium on day 14 of FET cycles, and their endometrial thicknesses were measured after 48?h of infusion. Main Outcome Measures The primary outcome was an increase in endometrial thickness and the secondary outcome measures were chemical and clinical pregnancies. Results The endometrial thickness increased from 5.86?±?0.58 to 6.58?±?0.84?mm after GCSF infusion. In 19 of the 35 participants (54.28?%) endometrial thickness increased to?≥7?mm and they subsequently underwent embryo transfer. Of these, 3 (15.78?%) patients had chemical pregnancy, but there was no clinical pregnancy. In 16 participants, embryo transfer was canceled in view of insufficient endometrial thickness ( Conclusion GCSF caused a small increase in endometrial thickness in women with persistent thin endometrium, but there was no improvement in their pregnancy rates.