The effect of Povidone-iodine on Peridural Fibrosis in Spinal Surgery

摘要

Aim: The purpose of this study was to evaluate whether povidone-iodine has any incremental effect on peridural fibrosis in spinal surgery.Materials and methods: 24 albino rats were used for this experimental study. They were divided into three groups. In the first group (n=8) only Th8-Th12 laminectomy was performed (control group). In the second group (n=8), laminectomy area was irrigated with 2.5% concentrated povidone-iodine for 30s seconds. In the third group (n=8), laminectomy area was irrigated with 10% concentrated povidone-iodine for 30 seconds. In pathological specimens, fibrosis length and fibrosis area was calculated and compared between groups.Results: Peridural fibrosis length and fibrosis area didn't show statistically significant difference between all groups.Conclusion: Povidone-iodine has not increasing effect on peridural fibrosis so it may be safely used in spinal surgery when it is needed.