Measurement of interrupter airway resistance (Rint) is a convenient alternative to standard spirometry for assessing respiratory function in uncooperative young children. The aim of the present prospective study was to establish the normative data and predictive equation of Rint in Japanese preschool children. A total of 214 children were enrolled from a single kindergarten; however, 129 were excluded because they met at least 1 of the exclusion criteria, such as wheezing history or recent common cold. Expiratory Rint values were assessed in 85 of the children, but technically unsatisfactory measurements were obtained in 5 of them. Thus, 80 healthy Japanese children (39 boys and 41 girls) without any history or symptoms of respiratory tract diseases were evaluated. Their age, body height, and body weight ranges (median) were 1.67 to 6.42 (4.38) years, 79.8 to 120.9 (102.5) cm, and 10.4 to 24.9 (15.8) kg, respectively. The mean Rint was 0.93±0.25 kPa/L/s (range=0.46-1.49 kPa/L/s). The Rint tended to decrease with increasing age and body height ( r =-0.65; P int (kPa/L/s) =2.513-0.01567×body height (cm) (multiple correlation coefficient=0.653). Because 79 of the 80 measured Rint values were within 140% of the predictive Rint value, we calculated a 140% cut-off for predicting bronchoconstriction. Our results provide a reference value for evaluating the degree of airway obstruction in young Japanese children.
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机译：测量中断呼吸道阻力（R int ）是一种标准肺活量测定的便捷替代方法，用于评估不合作的幼儿的呼吸功能。本前瞻性研究的目的是建立日本学龄前儿童的R int 的规范数据和预测方程。一所幼儿园共有214名儿童入学;但是，有129个被排除在外，因为它们至少符合一项排除标准，例如喘息史或最近的普通感冒。评估了85名儿童的呼气R int 值，但其中5名儿童的技术测量结果不理想。因此，对80名健康的日本儿童（39名男孩和41名女孩）没有呼吸道疾病的病史或症状进行了评估。它们的年龄，身高和体重范围（中位数）分别为1.67至6.42（4.38）岁，79.8至120.9（102.5）cm和10.4至24.9（15.8）kg。平均R int 为0.93±0.25 kPa / L / s（范围= 0.46-1.49 kPa / L / s）。 R int 随年龄和身高的增加而趋于下降（r = -0.65; P int（kPa / L / s）= 2.513-0.01567×身高（cm）（倍数）相关系数= 0.653）。因为在80个测量的R int 值中有79个在预测R int 值的140％以内，所以我们计算了140％的临界值我们的结果为评估日本年幼儿童的气道阻塞程度提供了参考价值。
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