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Characteristics of Biodegradable Implants

机译:可生物降解植入物的特征

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The development of synthetic biomaterials for bone fixations has greatly enhanced orthopedic surgery efficiency over the last two decades. With the advancement in medical technology, several materials such as metals, ceramics, polymers and composites have been considered over the years for possible implantation into the body. These materials however, must have the following required properties that will qualify them as potential medical devices: biocompatibility, mechanical properties, corrosion resistance, creep resistance, etc. The quest in making up for the disadvantages of metallic fixations has culminated in a paradigm shift to the use of biodegradable polymers. Biodegradable polymers are light-weight materials with low elastic moduli between 0.4 - 7 GPa. These materials can be engineered to degrade at rates that will slowly transfer load to the bone. In addition, complications like corrosion, release of metal ions and stress shielding associated with metal implants are eliminated. This review considers studies carried out on most commonly investigated and widely used synthetic biodegradable polymers, their successes and limitations. It also provides process for efficient utilization of these polymers as bone fixtures without inflammation and stress shielding.
机译:在过去的二十年中,用于骨固定的合成生物材料的发展大大提高了整形外科的手术效率。随着医疗技术的进步,多年来考虑使用多种材料,例如金属,陶瓷,聚合物和复合材料,以将其植入体内。但是,这些材料必须具有以下必需的属性,这些属性才有资格成为潜在的医疗设备:生物相容性,机械性能,耐腐蚀性,抗蠕变性等。弥补金属固定的缺点的追求最终导致了向使用可生物降解的聚合物。可生物降解的聚合物是重量轻的材料,其弹性模量在0.4至7 GPa之间。可以对这些材料进行工程设计,使其降解速度会缓慢地将负载转移到骨骼上。另外,消除了诸如腐蚀,金属离子释放和与金属植入物相关的应力屏蔽之类的复杂问题。这篇综述考虑了对最常研究和广泛使用的合成生物可降解聚合物的研究,它们的成功和局限性。它还提供了有效利用这些聚合物作为骨固定物而没有发炎和应力屏蔽的方法。

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