Barnoud , T. , Parris , J.L.D. , and Murphy , M.E. ( 2019a ). Common genetic variants in the TP53 pathway and their impact on cancer . J. Mol. Cell Biol. 11 , doi: Barnoud , T. , Parris , J.L.D. , and Murphy , M.E. ( 2019b ). Tumor cells containing the African-centric S47 variant of TP53 show increased Warburg metabolism . Oncotarget 10 , 1217 – 1223 . Beckman , G. , Birgander , R. , Sjalander , A. , et al. ( 1994 ). Is p53 polymorphism maintained by natural selection? Hum. Hered. 44 , 266 – 270 . Bensaad , K. , Tsuruta , A. , Selak , M.A. , et al. ( 2006 ). TIGAR, a p53-inducible regulator of glycolysis and apoptosis . Cell 126 , 107 – 120 . Chen , X. , Ko , L.J. , Jayaraman , L. , et al. ( 1996 ). p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells . Genes Dev. 10 , 2438 – 2451 . Derdak , Z. , Villegas , K.A. , Harb , R. , et al. ( 2013 ). Inhibition of p53 attenuates steatosis and liver injury in a mouse model of non-alcoholic fatty liver disease . J. Hepatol. 58 , 785 – 791 . Duan , L. , Perez , R.E. , Chen , L. , et al. ( 2018 ). p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a . J. Mol. Cell Biol. 10 , 331 – 340 . Eriksson , M. , Ambroise , G. , Ouchida , A.T. , et al. ( 2017 ). Effect of mutant p53 proteins on glycolysis and mitochondrial metabolism . Mol. Cell. Biol. 37 , pii: e00328-17 . Feng , Z. , Hu , W. , de Stanchina , E. , et al. ( 2007 ). The regulation of AMPK β1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1–AKT–mTOR pathways . Cancer Res. 67 , 3043 – 3053 . Freed-Pastor , W.A. , Mizuno , H. , Zhao , X. , et al. ( 2012 ). Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway . Cell 148 , 244 – 258 . Freed-Pastor , W.A. , and Prives , C. ( 2012 ). Mutant p53: one name, many proteins . Genes Dev. 26 , 1268 – 1286 . Gnanapradeepan , K. , Basu , S. , Barnoud , T. , et al. ( 2018 ). The p53 tumor suppressor in the control of metabolism and ferroptosis . Front. Endocrinol. 9 , 124 . Gorrini , C. , Harris , I.S. , and Mak , T.W. ( 2013 ). Modulation of oxidative stress as an anticancer strategy . Nat. Rev. Drug Discov. 12 , 931 – 947 . Gudkov , A.V. , and Komarova , E.A. ( 2010 ). Pathologies associated with the p53 response . Cold Spring Harb. Perspect. Biol. 2 , a001180 . Guo , J.Y. , and White , E. ( 2016 ). Autophagy, metabolism, and cancer . Cold Spring Harb. Symp. Quant. Biol. 81 , 73 – 78 . Hardie , D.G. ( 2014 ). AMPK—sensing energy while talking to other signaling pathways . Cell Metab. 20 , 939 – 952 . Hu , A. , Zhang , C. , Wu , R. , et al. ( 2010 ). Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function . Proc. Natl Acad. Sci. USA 107 , 7455 – 7460 . Hu , W. , Feng , Z. , Teresky , A.K. , et al. ( 2007 ). p53 regulates maternal reproduction through LIF . Nature 450 , 721 – 724 . Humpton , T.J. , Hock , A.K. , Maddocks , O.D.K. , et al. ( 2018 ). p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant . Cancer Metab. 6 , 18 . Humpton , T.J. , and Vousden , K.H. ( 2016 ). Regulation of cellular metabolism and hypoxia by p53 . Cold Spring Harb. Perspect. Med. 6 , pii: a026146 . Itahana , Y. , and Itahana , K. ( 2018 ). Emerging roles of p53 family members in glucose metabolism . Int. J. Mol. Sci. 19 , pii: E776 . Jennis , M. , Kung , C.P. , Basu , S. , et al. ( 2016 ). An African-specific polymorphism in the TP53 gene impairs p53 tumor suppressor function in a mouse model . Genes Dev. 30 , 918 – 930 . Jiang , D. , LaGory , E.L. , Kenzelmann Broz , D. , et al. ( 2015a ). Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function . Cell Rep. 10 , 1096 – 1109 . Jiang , L. , Kon , N. , Li , T. , et al. ( 2015b ). Ferroptosis as a p53-mediated activity during tumour suppression . Nature 520 , 57 – 62 . Jiang , P. , Du , W. , Mancuso , A. , et al. ( 2013 ). Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence . Nature 493 , 689 – 693 . Jiang , P. , Du , W. , Wang , X. , et al. ( 2011 ). p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase . Nat. Cell Biol. 13 , 310 – 316 . Jones , R.G. , Plas , D.R. , Kubek , S. , et al. ( 2005 ). AMP-activated protein kinase induces a p53-dependent metabolic checkpoint . Mol. Cell 18 , 283 – 293 . Kamphorst , J.J. , Nofal , M. , Commisso , C. , et al. ( 2015 ). Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein . Cancer Res. 75 , 544 – 553 . Khan , M.R. , Xiang , S. , Song , Z. , et al. ( 2017 ). The p53-inducible long noncoding RNA TRINGS protects cancer cells from necrosis under glucose starvation . EMBO J. 36 , 3483 – 3500 . Kung , C.P. , Leu , J.I. , Basu
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