Biomedical Application and Future Prospects of Transgenic Animal: Review

摘要

Today, transgenic animals represent one of the most potent and exciting research tools in the biological sciences.?A?transgenic animal is an animal into whose genome foreign Deoxyribose Nucleic Acid (DNA) has been transferred for the purpose of studying and manipulating that DNA. The establishment of stable transgenic animals implies that the foreign DNA is present in gametes or one cell embryos to allow its transmission to progeny. To reach this goal, the foreign gene can be transferred using different methods according to animal species. Several methods have been used for the production of transgenic animals like Microinjection of fertilized ovum, Embryonic stem (ES) cells mediated gene transfer and Retrovirus-mediated gene transfer. The study of human diseases is greatly facilitated by the generation of transgenic animals mimicking health disorders or allowing the evaluation of new pharmaceuticals.