Neutrophils constitute the first line of defense against invading pathogens, but they also are responsible for tissue destruction in pathological conditions. In a recent paper published in Science Signaling, Junger and colleagues show that adenosine 5′-triphosphate release and signaling through purinergic P2 receptors upon neutrophil activation by bacterial and inflammatory stimuli represents an important mechanism for effective neutrophil functional response and host protection.
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