首页> 外文期刊>Journal of Microbiology, Biotechnology and Food Sciences >EFFECTS OF TRIGONELLA FOENUM GRAECUM ON THE LEUKOCYTES IN DIABETES MICE
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EFFECTS OF TRIGONELLA FOENUM GRAECUM ON THE LEUKOCYTES IN DIABETES MICE

机译:三角叶草对糖尿病小鼠白细胞的影响

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Immunological disorders is among the most frequent and serious complications of diabetes mellitus An inflammatory response is usually accompanied by increasing leukocyte activation. Numerous medicinal plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological constituents and many of them are known to be effective against diabetes. Trigonella foenum-graecum Linn. (Leguminosae) commonly known as fenugreek, is an annual herb, widely grown in India, Egypt, and Middle Eastern countries. It has been extensively used as a source of antidiabetic compound, from its seeds and leaves. The aim of this study was to investigate anti-inflammatory effects of fenugreek on streptozotocin - induced diabetic mice. The animals were divided into four groups. Group I – control (C); Group II – diabetic untreated (DM); Group III –was administered purified from fenugreek (T. foenum-graecum) seeds (GII) in dose 100 mg.kg-1 body weight/day for 15 days (GII), and Group IV – diabetic treated with fenungreek (D+GII). Thirty minutes after the last injection animals were anaesthetized and decapitated. The blood samples were collected from the carotid artery. Were measured in blood lymphocytes, monocytes, neutrophils and eosinophils in stained blood films. The changes in analyzed parameters observed in the diabetes animals were also found to be significantly restored in fenugreek treated mice. The results demonstrated that extract of Trigonella foenum-graecum could be a potential herbal medicine in treating diabetes.
机译:免疫疾病是糖尿病最常见和最严重的并发症之一。炎症反应通常伴随着白细胞激活的增加。全球许多传统医学系统已将许多药用植物用于糖尿病的管理,因为它们是生物成分的重要来源,并且其中许多已知对糖尿病有效。三角叶草-亚麻(Leguminosae)通常被称为胡芦巴,是一年生草本植物,在印度,埃及和中东国家广泛种植。它的种子和叶子被广泛用作抗糖尿病化合物的来源。这项研究的目的是研究胡芦巴对链脲佐菌素诱导的糖尿病小鼠的抗炎作用。将动物分为四组。第一组-控制(C);第二组–未治疗的糖尿病(DM);第III组–从胡芦巴(T. foenum-graecum)种子(GII)中纯化,剂量为100 mg.kg-1体重/天,持续15天(GII),第IV组–用fenungreek(D + GII)治疗的糖尿病)。最后一次注射后30分钟,麻醉动物并使其断头。从颈动脉收集血样。在血膜中测定了血液中的淋巴细胞,单核细胞,嗜中性粒细胞和嗜酸性粒细胞。还发现在胡芦巴治疗的小鼠中糖尿病动物中观察到的分析参数的变化被显着恢复。结果表明,胡芦巴提取物可能是治疗糖尿病的潜在草药。

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