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Non-neoplastic findings at colonoscopy after positive faecal occult blood testing: Data from the English Bowel Cancer Screening Programme

机译:粪便潜血试验阳性后结肠镜检查的非肿瘤发现:来自英国肠癌筛查计划的数据

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Background The aim of the English Bowel Cancer Screening Programme (BCSP) is to diagnose early colorectal cancer and advanced adenomas. However, other findings are also reported at screening colonoscopy. Small studies demonstrate findings other than cancer or adenomas (non-neoplastic findings (NNF)) in 11–25%. Objectives and setting Describe the frequency and nature of NNF within the BSCP. Methods Data were obtained from the BCSP national database for all individuals undergoing colonoscopic investigation after positive faecal occult blood testing between August 2006 and November 2011. Data included demographics, smoking status, neoplastic findings and NNF. Results 121728 colonoscopies were analysed. ≥1 NNF were found in 26251 cases (21.6%). Diverticular disease (18875 cases) and haemorrhoids (7011) were the most frequently reported. Inflammatory bowel disease (IBD) was reported in 2152 cases. Individuals with a neoplastic diagnosis were less likely to have an NNF than those without (19.8% v 24.4%, p?
机译:背景技术英国肠癌筛查计划(BCSP)的目的是诊断早期大肠癌和晚期腺瘤。但是,在结肠镜检查中也发现了其他发现。小型研究表明,除癌症或腺瘤以外的其他发现(非肿瘤发现(NNF))为11–25%。目标和设置描述BSCP中NNF的频率和性质。方法2006年8月至2011年11月,从粪便潜血试验阳性后,从BCSP国家数据库中收集所有接受结肠镜检查的个体的数据。这些数据包括人口统计学,吸烟状况,肿瘤发现和NNF。结果分析了121728例结肠镜检查。 26251例患者中NNF≥1(21.6%)。憩室病(18875例)和痔疮(7011)是最常报告的。报告了2152例炎症性肠病(IBD)。具有肿瘤诊断的个体患NNF的可能性比没有患肿瘤的个体少(19.8%(%)对24.4%(%),p <0.001)。使用多变量分析对混杂因素进行调整后,老年患者仍伴有较小但具有统计学意义的NNF风险。结论BCSP产生大量NNF。发现一小部分人患有炎症性肠病(IBD)-是对长期治疗有重要意义的重要诊断。 BCSP参与者应注意,可能会发现除赘生物以外的其他发现,并且这些发现与该个体的相关性未知。结肠镜检查者对NNF的报道有所不同,潜在的报道不足是该研究的局限性。需要进一步研究以确定NNF对初级和二级保健的影响。

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