Experimental Evaluation of Healing Process of Burn-wound Treated by Lyophilized Aloe vera Dressing

摘要

In this research work, 30 albino rats were tested to evaluate the effectiveness of lyophilized Aloe vera dressing on wound healing process. The treatments were applied on the deep partial thickness burn wounds that were induced by modified electric solder. Three rats from each group were euthanatized on day 5, 10, 15, and 20 for tensile strength investigation. Another three rats were randomly selected from each group to be euthanatized on 24 hours (day 0) post-burn to determine the level of damage by histological study. Generally, the tensile strength increased on day 5 and 10 because of fibroblast activity and decreased on day 15 and 20 due to the rearrangement of the collagen. However, there is no significant difference (P<0.05) in the tensile strength s of both treated and control groups. The treated groups healed faster as compared to the control. The lyophilized Aloe vera dressing showed scar formation after 7 to 10 days of post-burn, and control showed scarring after 8-12 days of post-burn. However, all the wounds did not show any sign of infection, and no pustule was observed during the experimental period. Epithelialisation was observed in lyophilized Aloe vera dressing on day 5 and almost completed on day 10, whereas the control group showed signs of epithelialization only on day 15 and completed on day 20.