Drug Discovery and Bioinformatics of Marine Natural Products

摘要

Marine natural products covering 9% of biomedical compounds [1] have become a hot resource for drug discovery [2]. Interestingly, different extractions of natural products may yield different cellular functions.For example, algaehave been reviewed [3] to be anti-cancer, anti-inflammation, and anti-oxidative stress. In the organic extracts of red algae (Gracilariatenuistipitata), it is cytotoxic to oral cancer Ca9-22 cell lines, such as methanol extract of G. tenuistipitata (MEGT) [4] and ethanol extract of G. tenuistipitata (EEGT) [5]. Additionally, cultivation environment may also affect the bioactive metabolite content of marine algae [6].