Effect of Occupational Exposure on WBC Count and Oxidative Stress in Rice Mill Workers

摘要

Background: There are several occupations where individuals are exposed to high concentration of dust particles. The exposed dust can be organic, inorganic, bacterial toxins, viruses or lipopolysaccharides. Exposure to rice husk causes activation of eosinophils and in.ammation reactions. Cardiovascular diseases are associated with increased lipid peroxidation and decrease in levels of antioxidants. Aim & Objectives: Aim of the study was to evaluate the effect of occupational exposure on haematological and biochemical parameters of rice mill workers by analyzing blood cell Counts, Malondialdehyde (MDA), Nitric Oxide (NO) and Ascorbic acid. Material and Methods: A total of 134 eligible individuals who had been exposed to dust in rice mills for more than 5 years were included in the study group where as another 134 unexposed individuals constituted control group. Estimation of serum MDA, serum NO and plasma Ascorbic acid were done by using semiautoanalyzer. Results: There was no signi.cant difference between Total Leucocyte Count of exposed and unexposed individuals. Lymphocyte, monocyte, eosinophil and basophil counts are signi.cantly increased in exposed individuals. Serum levels of MDA, NO and Ascorbic acid are also signi.cantly increased in exposed group compared with control group. Conclusion: The .ndings of our study clearly indicate that the rice mill workers are under high level of dust exposure which has deleterious effects on their blood and tissues. Increased MDA, NO and decreased Vitamin-C are probably due to high oxidative stress.