Antioxidant and Cardioprotective Effect of Coconut Water against Doxorubicin Induced Cardiomyopathy.

摘要

Background: Cardiomyopathy is a chronic dis-order affecting the muscle of the heart. It mayresult in to heart failure. Aim: To investigatethe effects of coconut water on antioxidant andcardiac markers on doxorubicin induced cardi-omyopathy in wistar rats. Material and Meth-ods: 21 wistar rats were divided into 3 groupsof 7 rats per group. Group I served as Controlwhile Group II and Group III were administered2.5mg/Kg doxorubicin. Group III in additionwas administered with 3ml of coconut water for28 days. Results: The results obtained showedthat the level of Lactate Dehydrogenase (LDH),Aspartate Aminotransferase (AST) and AlanineAminotransferase were significantly increasedin Group II when compared with the ControlGroup (P0.05). On the other hand, the levelof antioxidant vitamins C and E were signifi-cantly decreased in Group II when comparedwith the Control Group. However, on the treat-ment with coconut water, the cardiac enzymeswere decreased while antioxidant vitamins im-proved. Conclusion:This could probably implythat coconut water possess beneficial antioxi-dant and cardioprotective potentials.