Chronic Urticaria Associated With Occult Papillary Thyroid Carcinoma and Dramatic Improvement After Total Thyroidectomy: A Retrospective Study From Turkey

摘要

Chronic urticaria (CU) is characterized by recurrent hives lasting more than 6 weeks, either alone or in combination with angioedema, and may persist for months to years [1]. It is classified as spontaneous or inducible and can be further classified into subtypes such as dermographic, cholinergic, aquagenic, solar, and cold-, heat-, or pressure-induced. The various triggers proposed include foods, drugs, infections, autoimmune comorbidities (including autoimmune thyroid disease), and cancer [1]. Recent reports indicated associations with hematological malignancies such as leukemia, lymphoma, and myeloma, as well as with carcinoma of the lung, bladder, testis, ovary, and thyroid gland, in particular papillary thyroid carcinoma. The dramatic recovery from urticaria after total thyroidectomy in cases of thyroid carcinoma suggests a causal relationship (Table) [2-5]. The aim of this study was to analyze the frequency of thyroid carcinoma and outcome of treatment among patients with chronic urticaria.