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首页> 外文期刊>Journal of Lipid Research >Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics
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Genetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics

机译:通过加勒比海裔西班牙裔的联系和关联分析确定了血脂水平的遗传基因座

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摘要

To identify genetic loci influencing blood lipid levels in Caribbean Hispanics, we first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and LDL-C/HDL-C ratio. We then investigated the association between blood lipid levels and 21,361 single nucleotide polymorphisms (SNP) under the 1-logarithm of odds (LOD) unit down regions of linkage peaks in an independent community-based subcohort (N = 814, 42% Dominican) from the Northern Manhattan Study (NOMAS). We found significant linkage evidence for LDL-C/HDL-C on 7p12 (multipoint LOD = 3.91) and for TC on 16q23 (LOD = 3.35). In addition, we identified suggestive linkage evidence of LOD 2.0 on 15q23 for TG, 16q23 for LDL-C, 19q12 for TC and LDL-C, and 20p12 for LDL-C. In the association analysis of the linkage peaks, we found that seven SNPs near FLJ45974 were associated with LDL-C/HDL-C with a nominal P 3.5 x 10-5, in addition to associations (P 0.0001) for other lipid traits with SNPs in or near CDH13, SUMF2, TLE3, FAH, ARNT2, TSHZ3, ZNF343, RPL7AL2, and TMC3. Further studies are warranted to perform in-depth investigations of functional genetic variants in these regions.
机译:为了确定影响加勒比西班牙裔人群血脂水平的遗传基因座,我们首先对100个多米尼加家庭的1,211名受试者进行了全基因组连锁扫描,涉及五个脂质定量特征:总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C),高密度脂蛋白胆固醇(HDL-C),甘油三酸酯(TG)和LDL-C / HDL-C比率。然后,我们调查了一个独立的以社区为基础的亚人群(N = 814,42%多米尼加)中血脂水平与21 361个单核苷酸多态性(SNP)在比对数(LOD)单位下降区域的连接峰下的关联(N = 814,42%多米尼加)曼哈顿北部研究(NOMAS)。我们发现Lp-C / HDL-C在7p12(多点LOD = 3.91)和TC在16q23(LOD = 3.35)上有重要的连锁证据。此外,我们在TG的15q23,LDL-C的16q23,TC和LDL-C的19q12以及LDL-C的20p12上发现了LOD> 2.0的暗示连锁证据。在连锁峰的关联分析中,我们发现FLJ45974附近的七个SNP与LDL-C / HDL-C关联,标称P <3.5 x 10-5,此外还与其他脂质性状关联(P <0.0001) CDH13,SUMF2,TLE3,FAH,ARNT2,TSHZ3,ZNF343,RPL7AL2和TMC3中或附近的SNP。有必要进行进一步的研究以对这些区域的功能性遗传变异进行深入的研究。

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