Validation of circulating BNP level >1000?pg/ml in all-cause mortality: A retrospective study

摘要

Aim To determine the primary diseases and prognoses of patients with highly elevated levels of B-type natriuretic peptide (BNP; >1000?pg/ml), with or without heart failure. Methods Medical records and echocardiograms of patients with BNP levels that fell within one of three predetermined categories (>1000?pg/ml, 200–1000?pg/ml and 1000?pg/ml (n?=?103) or 200–1000?pg/ml (n?=?100) had significantly worse 3-year survival than those with BNP levels 1000?pg/ml group had heart failure. The main cause of death in patients with other causes of BNP levels >1000?pg/ml (39/103) was community acquired pneumonia. Conclusion A BNP level >1000?pg/ml has clinical importance in primary care medicine and hospital settings.