Phytochemical investigation and antimicrobial activity of an endophytic fungus Phoma sp.

摘要

Phytochemical investigation of the endophytic fungi Phoma sp. resulted in the isolation of sclerodin ( 1 ), 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4 H -phenaleno[1,2- b ]furan-4,6(5 H )-dione ( 2 ), atrovenetinone ( 3 ), and sclerodione ( 4 ). Preliminary studies showed that sclerodin ( 1 ) displayed moderate antialgal activity while 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4 H -phenaleno[1,2- b ]furan-4,6(5 H )-dione ( 2 ), atrovenetinone ( 3 ), and sclerodione ( 4 ) displayed moderate antifungal activity. Furthermore 8,9-dihydro-3,5,7-trihydroxy-1,8,8,9-tetramethyl-5-(2-oxopropyl)-4 H -phenaleno[1,2- b ]furan-4,6(5 H )-dione ( 2 ) and atrovenetinone ( 3 ) showed moderate antibacterial activity against Bacillus megaterium and additionally atrovenetinone ( 3 ) showed good antibacterial activity towards Eurotium repens . Furthermore atrovenetinone ( 3 ) and sclerodione ( 4 ) displayed very strong antifungal activity towards Ustilago violacea .