Correlation of Basic Fibroblast Growth Factor Expression in Palatal Mucoperiosteal Tissue with Dental Arch Relationships in Operated Unilateral Cleft Lip and Palate Patients

摘要

Scar formation after palate repair affects maxillary growth in patients with cleft lip and palate. In a previous study on denuded rat palate, basic fibroblast growth factor (bFGF) administration suppressed the postoperative scar formation. We analyzed the correlation between bFGF expression in palatal mucoperiosteal tissue and maxillary growth using the Great Ormond Street, London and Oslo (GOSLON) Yardstick in operated unilateral cleft lip and palate patients. GOSLON Yardstick from dental casts of 8 operated cleft lip and palate patients was used. Palatal mucoperiosteal tissue samples were collected from the cleft patients during alveolar bone grafting surgery. Microscopic analysis with immunohistochemistry and modified Masson’s trichrome were performed. GOSLON Yardstick and bFGF expression in palatal mucoperiosteal tissue showed a strong negative correlation (r = ?0.637, Spearman test). Further, this expression differed significantly between the favorable and unfavorable GOSLON groups (P < 0.05, Mann-Whitney test). GOSLON Yardstick and modified Masson’s trichrome staining results showed a strong positive correlation (r = 0.900, Spearman test). bFGF expression was correlated with dental arch relationships in operated cleft lip and palate patients wherein it regulated collagen fiber formation and minimized scar formation. bFGF may promote maxillary growth after cleft lip and palate repair.