Changes of proinflammatory, fluid balance, vascular permeability and oxidative stress in patients with secretory otitis media

摘要

Objective: To investigate the changes of proinflammatory, fluid balance, vascular permeabilityand oxidative stress in patients with secretory otitis media. Methods: A total of 42 patientswith secretory otitis media treated in our hospital from September 2016 to January 2018were selected as the observation group and 42 healthy people as the control group. Thelevels of proinflammatory effect [including transforming growth factor beta 1 (TGF-β1),transforming growth factor-beta 2 (TGF-β2)], fluid balance [including aquaporin-1 (AQP-1)and aquaporin-4 (AQP-4)], vascular permeability [including hyaluronic acid (HA), fibronectin(Fn) and platelet activating factor (PAF)] and oxidative stress-related indexes [includingmalondialdehyde (MDA) and superoxide dismutase (SOD)] were observed and comparedbetween the two groups. Results: The levels of AQP-1, AQP-4 and Fn in the observationgroup were significantly lower than those in the control group. The expression levels were(4.52±0.39) g/L, (23.06±7.21) g/L and (120.59±13.07) mg/L, respectively. The levels of TGF-β1, TGF-β2, HA, PAF, MDA and SOD were significantly higher than those of the controlgroup and the expression levels were (11.99±4.23) 毺g/L, (4.22±1.66) 毺g/L, (70.54±6.99) 毺g/L, (123.83±20.58) ng/mL, (6.30±0.44) nmol/mL and (15.85±0.78) NU/mL, respectively. Thedifference was statistically significant. Conclusions: Inflammatory reaction occurs in patientswith otitis media with secretory otitis media. It is easy to break the liquid balance in the middleear cavity and to increase vascular permeability and oxidative stress. The relevant indicatorsshould be strengthened in clinical practice, so as to provide evidence for early diagnosis andtreatment of the disease.