Correlation of serum CRP and PCT levels with systemic inflammatory response in patients with acute exacerbation of COPD

摘要

Objective: To investigate the correlation of serum C-reactive protein (CRP) and procalcitonin(PCT) levels with systemic inflammatory response in patients with acute exacerbation ofchronic obstructive pulmonary disease (COPD). Methods: 68 patients with acute exacerbationof COPD treated in our hospital between August 2012 and February 2016 were collectedas observation group and 50 normal subjects receiving physical examination in our hospitalduring the same period were selected as normal control group. Radioimmunoassay was usedto determine serum CRP and PCT levels; the observation group was further grouped accordingto the median of CRP and PCT levels, and serum levels of pro-inflammatory factors, antiinflammatoryfactors and stress hormones of high level group and low level group weredetected. Results: Serum CRP and PCT levels of observation group were significantly higherthan those of normal control group (P0.05); serum pro-inflammatory factors interleukin-1β(IL-1β), interleukin-6 (IL-6) and interleukin-8 (IL-8) levels of high CRP and PCT level groupswithin observation group were higher than those of low CRP and PCT level groups (P0.05),anti-inflammatory factors interleukin-4 (IL-4) and interleukin-13 (IL-13) levels were lowerthan those of low CRP and PCT groups (P0.05), and stress hormones angiotensin II (Ang II),aldosterone (ALD) and cortisol (Cor) levels were higher than those of low CRP and PCT levelgroups (P0.05). Conclusions: Serum CRP and PCT levels in patients with acute exacerbationof COPD are positively correlated with the inflammatory response extent in the body, andcan be used as the auxiliary means for early disease diagnosis, treatment effect evaluation andprognosis judgment.