Effect of peritoneal dialysis on inflammatory factors, nutritional index and renal function in patients with chronic renal failure

摘要

Objective: To explore the effect of peritoneal dialysis on inflammatory factors, nutritionalindex and renal function indexes in patients with chronic renal failure, and to provide help forclinical treatment of patients with chronic renal failure. Methods: 80 cases of chronic renalfailure patients in our hospital were selected as the study group, given peritoneal dialysistreatment; 80 healthy people during the same period in our hospital selected as the normalgroup. The inflammatory factors [C-reactive protein (CRP), interleukin-6 (IL-6), tumornecrosis factor-α (TNF-α) and IL-8], renal function indices [BUN (Urea nitrogen) and SCR(serum creatinine)] and nutritional index [PA (prealbumin), Hb (hemoglobin), ALB (albumin)and TF (Transferrin)] levels were detected in healthy population and patients with chronicrenal failure patients before and after treatment of 1 and 30 d, and the relative significancewas analyzed. Results: Compared with the normal group, the inflammatory factors (CRP,IL-6, TNF-α and IL-8) and renal function indices (BUN and SCR) of patients with chronicrenal failure in study group increased significantly and nutritional indexes (TF, PA and ALB)decreased significantly (P0.05). The inflammatory factors (CRP, IL-6, TNF-α and IL-8),nutritional index (TF, PA and ALB) and renal function indices (BUN and SCR) of patientswith chronic renal failure by peritoneal dialysis in the treatment of 1 d in research group weresignificantly lower than the level before treatment, and Hb was significantly higher than thatbefore treatment (P0.05). After 30 d of dialysis, inflammatory factors (CRP, IL-6, TNF-αand IL-8), nutritional index (TF, PA and ALB) and renal function indices (BUN and SCR)decreased further and Hb increased further (P0.05). Conclusions: Peritoneal dialysis canimprove the inflammatory factors levels of patients with chronic renal failure, reduce the renalfunction index, and can affect the nutritional index of patients, and has important significancein clinical treatment of patients with chronic renal failure.