Effect of immunotherapy combined with intravenous chemotherapy on the tumor load, immune function and cancer cell proliferation activity in patients with advanced colon cancer

摘要

Objective: To study the effect of immunotherapy combined with intravenous chemotherapyon the tumor load, immune function and cancer cell proliferation activity in patients withadvanced colon cancer. Methods: A total of 90 patients with advanced colon cancer who weretreated in Second People’s Hospital of Yibin between December 2014 and January 2017 werecollected and divided into control group (n=45) and observation group (n=45) by randomnumber table. Control group received routine intravenous chemotherapy, and the observationgroup received immunotherapy combined with intravenous chemotherapy. The levels ofspecific tumor markers and Th17/Treg cytokines in serum as well as proliferation geneexpression in the lesion tissue were determined. Results: Before treatment, the differencesin levels of specific tumor markers and Th17/Treg cytokines in serum as well as proliferationgene expression in lesion tissue were not statistically significant between the two groups.After treatment, PTN, CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 andPIK3CB mRNA expression in lesion tissue of both groups of patients were lower than thosebefore treatment while IL-10 and IL-35 levels in serum as well as FAM96B, MS4A12 andFRAT1 mRNA expression in lesion tissue were higher than those before treatment, and PTN,CCSA-1, IL-17 and IL-23 levels in serum as well as GTPBP4 and PIK3CB mRNA expressionin lesion tissue of observation group were lower than those of control group while IL-10 andIL-35 levels in serum as well as FAM96B, MS4A12 and FRAT1 mRNA expression in lesiontissue were higher than those of control group. Conclusion: Immunotherapy combined withintravenous chemotherapy can effectively reduce the tumor load, optimize cellular immunefunction and inhibit tumor cell proliferation in patients with advanced colon cancer.