Effect of Er, Cr: YSGG laser combined with oral basic treatment on inflammatory injury and apoptosis in patients with periodontitis

摘要

Objective: To study the effect of Er, Cr: YSGG laser combined with oral basic treatment oninflammatory injury and apoptosis in patients with periodontitis. Methods: Patients withchronic periodontitis who were treated in dental clinic of our hospital between February 2015and March 2017 were selected as the research subjects and randomly divided into the groupA who accepted ultrasonic dental cleaning, hand scaling combined with Er, Cr: YSGG lasertreatment and the group B who received ultrasonic dental cleaning and hand scaling treatment.The contents of inflammatory response cytokines, protease molecules and apoptosis moleculesin gingival crevicular fluid were detected before treatment and 1 week after treatment. Results:TNF-α, hs-CRP, IL-1β, IL-6, IL-8, EMMPRIN, CyPA, MMP2, MMP9, Smac, Bax, Fas andFasL contents in gingival crevicular fluid of both groups of patients 1 week after treatmentwere significantly lower than those before treatment, and TNF-α, hs-CRP, IL-1β, IL-6, IL-8,EMMPRIN, CyPA, MMP2, MMP9, Smac, Bax, Fas and FasL contents of group A 1 weekafter treatment were significantly lower than those of group B. Conclusion: Er, Cr: YSGGlaser combined with oral basic treatment can inhibit the inflammatory injury and apoptosis inperiodontal tissue of patients with periodontitis.