Effect of Qingre Yangyin Humo prescription on serum indexes in esophageal cancer radiotherapy

摘要

Objective: To study the effectiveness of Qingre Yangyin Humo prescription in preventingradioaction esophagitis and its effect on the serum radiation damage indexes. Methods:Patients with advanced esophageal cancer who received radiotherapy in the First AffiliatedHospital of Bengbu Medical College between June 2015 and December 2016 were selected asthe research subjects and randomly divided into two groups, the intervention group receivedQingre Yangyin Humo prescription during radiotherapy, and the control group received regularintervention during radiotherapy. The incidence of radiation esophagitis within 90 days afterradiotherapy was observed, and serum inflammation indexes, oxidative stress indexes andpulmonary fibrosis index were determined before radiotherapy as well as 2 weeks and 4 weeksafter radiotherapy. Results: After radiotherapy, serum TNF-α, IL-1β, IL-6, IL-8, MDA,8-OHdG, MMP9, TGF-β1 and ACE levels of both groups were significantly higher than thosebefore radiotherapy while GPX1, T-SOD and Mn-SOD levels were significantly lower thanthose before radiotherapy, and serum TNF-α, IL-1β, IL-6, IL-8, MDA, 8-OHdG, MMP9,TGF-β1 and ACE levels of intervention group were significantly lower than those of controlgroup while GPX1, T-SOD and Mn-SOD levels were significantly higher than those of controlgroup. Conclusion: Qingre Yangyin Humo prescription can prevent the occurrence of radiationesophagitis and reduce radiation damage during radiotherapy.