Effects of Danzhi Xiaoyao pill combined with metformin on related factors in patients with polycystic ovary syndrome

摘要

Objective: To study the clinical efficacy and effects of danzhi xiaoyao pill combined with metformin on related factors in patients with polycystic ovary syndrome (PCOS). Methods: A total of 80 patients with PCOS in our hospital from January 2014 to December 2017 were enrolled in this study. The subjects were divided into the control group (n=40) and the experimental group (n=40) randomly. The control group were treated with metformin, the experimental group were treated with danzhi xiaoyao pill combined with metformin, and the two groups were treated for 3 menstrual cycles. The serum CRP, IGF-1, TNF-α, FSH, LH, E2, T, FINS, FPG, VF, LEP, APN and HOMA-IR of the two groups before and after treatment were compared. Results: There were no significantly differences of the serum CRP, IGF-1, TNF-α , FSH, LH, E2, T, FINS, FPG, VF, LEP, APN and HOMA-IR of the two groups before treatment. After treatment, the serum CRP, IGF-1, TNF-α, LH, E2, T, FINS, FPG, VF, LEP and HOMA-IR of the two groups were significantly lower than before treatment, the serum APN of the two groups were significantly higher than before treatment, and that of the experimental group after treatment were significantly better than the control group. Conclusion: Danzhi xiaoyao pill combined with metformin on patients with PCOS has a good efficacy. It can reduce the inflammatory cytokines and sex hormones, and improve the insulin resistance and sugar, lipid metabolic disorders. Therefore, it is worthy of clinical application.