Effects of postoperative dexmedetomidine sedation on nerve function, inflammation and oxidative stress in patients with craniocerebral injury

摘要

Objective: To study the effects of postoperative dexmedetomidine sedation on nerve function, inflammation and oxidative stress in patients with craniocerebral injury. Methods: Patients who were admitted to ICU and needed sedation and analgesia after craniocerebral injury craniotomy in Huiya Hospital between June 2016 and October 2017 were selected as the research subjects and divided into the Dex group who accepted postoperative dexmedetomidine sedation and the control group who accepted postoperative midazolam sedation according to the history data. The levels of nerve markers and inflammation molecules in serum as well as the expression of oxidative stress molecules in peripheral blood were measured before surgery as well as 24 h and 48 h after surgery. Results: Compared with those before surgery, UCH- L1, NSE, GFAP, sFkn, CXCL12, IL-1β and sICAM1 levels in serum as well as Nrf2, NQO1, HO1, NOX2 and NOX4 expression in peripheral blood of both groups decreased significantly whereas BDNF and NGF levels increased significantly 24 h and 48 h after surgery, and UCH- L1, NSE, GFAP, sFkn, CXCL12, IL-1β and sICAM1 levels in serum as well as Nrf2, NQO1, HO1, NOX2 and NOX4 expression in peripheral blood of Dex group 24 h and 48 h after surgery were significantly lower than those of control group whereas BDNF and NGF levels were significantly higher than those of control group. Conclusion: Dexmedetomidine for postoperative sedation can be more effective than midazolam to improve the nerve function, and reduce the inflammation and oxidative stress in patients with craniocerebral injury.