Correlation of NSE and ProGRP levels in patients with small cell lung cancer before and after chemotherapy with cancer cell apoptosis caused by chemotherapy

摘要

Objective: To study the correlation of NSE and ProGRP levels in patients with small celllung cancer (SCLC) before and after chemotherapy with cancer cell apoptosis caused bychemotherapy. Methods: Patients with SCLC accepting EP chemotherapy in our hospitalbetween August 2014 and October 2016 were selected, serum was collected beforechemotherapy and after 3 cycles of chemotherapy respectively to determine NSE and ProGRPlevels, the quartile of serum NSE and ProGRP levels after chemotherapy were referred todivide the patients into NSE and ProGRP-1 group, -2 group, -3 and -4 group from low tohigh; tumor lesions were collected to determine apoptosis molecule mRNA expression.Results: After chemotherapy, serum NSE and ProGRP levels of patients with SCLC weresignificantly lower than those before chemotherapy, and Fas, FasL, Caspase-8, Caspase-3,pULK and PI3KC3 mRNA expression in tumor lesion were significantly higher than thosebefore chemotherapy; Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3 mRNA expressionin lesions of NSE and ProGRP-1 group, -2 group and -3 group were significantly higher thanthose of NSE and ProGRP-4 group, Fas, FasL, Caspase-8, Caspase-3, pULK and PI3KC3mRNA expression in lesions of NSE and ProGRP-1 group and -2 group were significantlyhigher than those of NSE and ProGRP-3 group, and Fas, FasL, Caspase-8, Caspase-3, pULKand PI3KC3 mRNA expression in lesions of NSE and ProGRP-1 group were significantlyhigher than those of NSE and ProGRP-2 group. Conclusion: Serum NSE and ProGRP levelsdecrease significantly in patients with small cell lung cancer after chemotherapy, and they areclosely related to the cancer cell apoptosis caused by chemotherapy.