Effect of argatroban on neurological function in patients with acute cerebral infarction and its mechanism

摘要

Objective: Analyze the effect of argatroban on neurological function in patients with acutecerebral infarction and explore its possible mechanisms. Methods: From August 2015 toAugust 2017, 140 patients with acute cerebral infarction who were admitted to the Departmentof Neurology in our hospital were divided into a control group and an observation groupaccording to the lottery method, with 70 cases in each group. Patients in the conventionalgroup received routine treatment. Patients in the treatment group received routine treatmentplus argatroban. The changes of neurological function, coagulation function and inflammatoryfactors were observed in the two groups. Result: Before treatment, there were no significantdifferences in neurological function parameters, coagulation function indexes and inflammatoryfactors between the two groups. After treatment, the neurological function indexes NT-proBNP,NPY and S-100β levels, coagulation function index FIB level, inflammatory factor indicatorsMMP-9, Lp-PLA2 and Hcy, vascular endothelial function index ET levels decreased,coagulation Functional indicators PT, TT and APTT are both elevated, and NO and CGRPlevels are elevated. The levels of NT-proBNP, NPY and S-100β, FIB level, MMP-9, Lp-PLA2and Hcy, ET levels in the treatment group were lower than those in the conventional group,while the levels of PT, TT and APTT levels, and NO and CGRP levels were higher than theconventional group. Conclusion: Argatroban treatment can significantly improve neurologicalfunction in patients with acute cerebral infarction. The possible mechanism is to improvecoagulation function, vascular endothelial function and relieve inflammatory stress response.