Effect of early enteral immunonutrition intervention on gastrointestinal hormones, stress hormones and immune response after pancreatic cancer surgery

摘要

Objective: To study the effect of early enteral immunonutrition intervention on gastrointestinalhormones, stress hormones and immune response after pancreatic cancer surgery. Methods:A total of 68 patients who received radical operation for pancreatic cancer in Chengdu ThirdPeople’s Hospital between May 2015 and February 2017 were selected as the research subjectsand randomly divided into TPF-T group and TP group who received early postoperative enteralimmunonutrition intervention and conventional enteral nutrition intervention respectively.The levels of gastrointestinal hormones MTL, GAS, CGRP, Ghrelin and stress hormonesACTH, Cor,R, AT-II, ALD in serum as well as the levels of immune cells CD4+T, CD8+T,NKT, Treg, Breg, MDSC in peripheral blood were detected before surgery as well as 3 d and7 d after surgery. Results: 3 d and 7 d after surgery, MTL, GAS, CGRP and Ghrelin levelsin serum as well as CD4+T cell, CD8+T cell and NKT cell levels in peripheral blood of bothgroups of patients were significantly lower than those before surgery while ACTH, Cor, R, ATIIand ALD levels in serum as well as Treg, Breg and MDSC levels in peripheral blood weresignificantly higher than those before surgery, and MTL, GAS, CGRP and Ghrelin levels inserum as well as CD4+T cell, CD8+T cell and NKT cell levels in peripheral blood of TPF-Tgroup were significantly higher than those of TP group while ACTH, Cor, R, AT-II and ALDlevels in serum as well as Treg, Breg and MDSC levels in peripheral blood were significantlylower than those of TP group. Conclusion: Early postoperative enteral immunonutritionintervention can regulate the gastrointestinal hormone secretion, inhibit stress response andimprove immune response.