Effect of glutamine nutrition support on the intestinal mucosal barrier function and inflammatory response in patients with severe acute pancreatitis

摘要

Objective: To study the effect of glutamine nutrition support on the intestinal mucosal barrierfunction and inflammatory response in patients with severe acute pancreatitis. Methods:Patients with severe acute pancreatitis who were treated in Pengzhou People’s Hospitalbetween May 2014 and November 2016 were selected as the research subjects and randomlydivided into two groups, control group received conventional symptomatic treatment andconventional enteral nutrition intervention, and Gln group received conventional symptomatictreatment and glutamine enteral nutrition intervention. The contents of intestinal mucosalbarrier damage markers and inflammatory mediators in serum as well as the expressionof inflammatory signaling molecules in peripheral blood were detected before and aftertreatment; the number of intestinal flora was detected after treatment. Results: After treatment,LPS, DAO, HBD2, TNF-α, sTREM-1, IL-1β and IL-6 levels in serum as well as TLR4,NF-kB, MyD88 and p38MAPK mRNA expression in peripheral blood mononuclear cellsof both groups of patients were significantly lower than those before treatment, LPS, DAO,HBD2, TNF-α, sTREM-1, IL-1β and IL-6 levels in serum as well as TLR4, NF-kB, MyD88and p38MAPK mRNA expression in peripheral blood mononuclear cells of Gln group aftertreatment were significantly lower than those of control group, and the number of lactobacillus,bifidobacterium and bacteroides were significantly higher than those of control group whilethe number of escherichia coli and enterococcus were significantly lower than those of controlgroup. Conclusion: Glutamine nutrition support for severe acute pancreatitis can reduce theintestinal mucosal barrier function injury and inhibit the inflammatory response activation.