Effect of rosuvastatin on the vascular endothelial function and inflammatory cytokine in patients after PCI

摘要

Objective: To evaluate the effect of rosuvastatin on the vascular endothelial function andinflammatory cytokine in patients after PCI. Methods: A total of 120 patients with ACS whowere admitted in our hospital from December, 2014 to June, 2016 were included in the studyand randomized into the observation group and the control group. PCI was performed in thetwo groups. The patients in the control group were given routine treatments. On this basis, thepatients in the observation group were given rosuvastatin (20 mg) 3 d before operation, everynight before sleep, continuously for 1 month. The efficacy was evaluated 24 h and 1 monthafter operation. Hs-CRP, IL-10, TNF-毩, vWF, ET-1, NO, TG, TC, and LDL levels beforeoperation, 24 h and 1 month after operation in the two groups were detected. Results: vWFand ET-1 levels 1 month after operation in the observation group were significantly lower thanthose in the control group, while NO was significantly higher than that in the control group.hs-CRP, IL-10, and TNF-毩 24 h and 1 month after operation in the observation group weresignificantly lower than those in the control group. TC, TG, and LDL levels 24 h and 1 monthafter operation in the observation group were significantly lower than those in the controlgroup. Conclusions: Rosuvastatin can effectively reduce the serum inflammatory cytokinelevel, improve the vascular endothelial function, and decrease the occurrence of thrombus andrestenosis in patients with ACS after PCI.