Effect of low-rTMS in combined with edaravone on the inflammatory cytokines and cerebral metabolites in patients with cerebral infarction and aphasia

摘要

Objective: To explore the effect of low-repetitive transcranial magnetic stimulation (low-rTMS)in combined with edaravone on the inflammatory cytokines and cerebral metabolites in patientswith cerebral infarction and aphasia. Methods: A total of 70 patients with acute cerebralinfarction (ACI) and motor aphasia who were admitted in our hospital from March, 2015 toMarch, 2016 were included in the study and randomized into the observation group and thecontrol group, 35 in each group. The patients in the control group were given blood pressurereduction, intracranial pressure reduction, blood lipid regulation, anti-platelet aggregation,symptomatic and supportive treatments, edaravone (30 mg) + normal saline (100 mL), ivdrip,2 times/d, continuously for 2 weeks. On this basis, the patients in the observation group weregiven additional rTMS, continuously for 10 d. Hs-CRP, IL-6, IL-8, and TNF-α levels beforetreatment, 1 week and 2 weeks after treatment in the two groups were detected. MRS was usedto detect NAA and Cho in Broca district before treatment, 1 week and 2 weeks after treatmentin the two groups. ABC was used to evaluate the linguistic function before treatment, 2 weeks,3 months, and 6 months in the two groups. Results: Hs-CRP, IL-6, IL-8, and TNF-α levels 1week and 2 weeks after treatment in the observation group were significantly lower than thosein the control group (P0.05). NAA value on the left side 1 week and 2 weeks after treatmentin the observation group was significantly higher than that in the control group (P0.05), whileCho value was significantly lower than that in the control group (P0.05). ABC score 2 weeks,3 months, and 6 months after treatment in the observation group was significantly higher thanthat in the control group (P0.05). Conclusions: Edaravone in combined with low-rTMS in thetreatment of ACI can effectively inhibit the inflammatory reaction, improve the neurologicaldeficit degree, and promote the recovery of cortex language neural network.