Effect of bushen tiaopi recipe on sex hormones, immune function and oxidative stress in patients with climacteric syndrome

摘要

Objective: To explore the effect of Bushen Tiaopi Recipe on sex hormones, immune function and oxidative stress in patients with climacteric syndrome and guide clinical medication. Methods: A total of 140 cases of climacteric syndrome patients who were treated in our hospital from May 2016 to May 2017 were selected according to the lottery method, 70 cases in each group. Control group was given Li Fumin treatment, and the observation group was given Li Fumin combined with Bushen Tiaopi Recipe. The levels of sex hormones, T lymphocyte subsets, leptin, adiponectin and oxidative stress were measured before and after treatment in both groups. Result: There was no significant difference in the levels of sex hormones, T lymphocyte subsets, leptin, adiponectin and oxidative stress before treatment between the two groups. After 12 weeks of drug treatment, the level of sex hormone P increased and the levels of LH and FSH decreased in both groups. And the research group P was (21.89±2.29) nmol/L higher than the control group, and the LH and FSH were (4.28±0.43) IU/L and (4.91±0.50) IU/L were lower than the control group. The LP level was decreased and the APN level increased in both groups. Moreover LP level in the research group was (15.34±1.52) μg/L lower than that in the control group, and the APN level was (8.39±0.84) mg/ L higher than that in the control group. The SOD level was increased and MDA level decreased in both groups. And SOD level in the research group was (33.27±3.29) U/L, which was higher than that in the control group, and the MDA level was (12.47±1.25) nmol/mL, which was lower than that in the control group. CD4 + and CD4 + /CD8 + levels were significantly elevated in both groups, and CD8 + levels were significantly decreased. In the research group, CD4 + and CD4 + /CD8 + were (28.87±2.69)% and (1.41±0.14), respectively, higher than the control group, and the number of CD8 + cells was (21.05±2.23)% lower than the control group. Conclusion: Bushen Tiaopi can significantly improve sex hormone levels in climacteric syndrome patients, improve immune function, relieve oxidative stress, and improve treatment effects.