Relationship between miR-100 expression in cervical cancer tissue and cisplatin resistance

摘要

Objective: To study the relationship between miR-100 expression in cervical cancer tissueand cisplatin resistance. Methods: A total of 107 cases of cervical cancer tissues from thosewho received cisplatin chemotherapy in Huanggan Central Hospital between May 2013and October 2016 were collected as the clinical samples and divided into chemotherapyresponsivecisplatin-sensitive cervical cancer tissue and chemotherapy-irresponsive cisplatinsensitivecervical cancer tissue according to the curative effect of chemotherapy. The miR-100 expression as well as the expression of drug resistance-related genes, cell cycle-relatedgenes and cell invasion-related genes was determined. Results: The miR-100 expression incisplatin-resistant cervical cancer tissue was significantly lower than that in cisplatin-sensitivecervical cancer tissue while Nek2, P-gp, GST-π, Topo-II, SP2, CyclinD1, CyclinG1, CDK4,CDK5, MMP1, PAR1, RbAp48, Vimentin and N-cadherin expression were significantlyhigher than those in cisplatin-sensitive cervical cancer tissue; the miR-100 expression wasnegatively correlated with Nek2, P-gp, GST-π, Topo-II, SP2, CyclinD1, CyclinG1, CDK4,CDK5, MMP1, PAR1, RbAp48, Vimentin and N-cadherin expression. Conclusion: The lowerexpression of miR-100 in cervical cancer tissue is closely associated with cisplatin resistance.