Correlation of EEG characteristics with serum cytokines, nerve molecules and apoptosis molecules in patients with epilepsy

摘要

Objective: To study the correlation of electroencephalogram characteristics with serumcytokines, nerve molecules and apoptosis molecules in patients with epilepsy. Methods:Patients who were diagnosed with epilepsy in the First Hospital of Yulin between March 2015and February 2017 were selected as the epilepsy group of the research and healthy subjectswho received physical examination in the First Hospital of Yulin during the same period wereselected as the control group. EEG examination was conducted to determine EEG dischargeindex, and serum was collected to determine the contents of cytokines, nerve molecules andapoptosis molecules. Results: EEG discharge index of epilepsy group was significantly higherthan that of control group; serum IL-2, TNF-α, IFN-γ, HMGB-1, S100B, NSE, GFAP, Baxand Caspase-3 contents of epilepsy group were significantly higher than those of control groupand positively correlated with EEG discharge index while CGRP and Bcl-2 contents weresignificantly lower than those of control group and negatively correlated with EEG dischargeindex. Conclusion: The abnormal neuron discharge in patients with epilepsy is associatedwith the abnormal secretion of immune and inflammatory cytokines and can cause excessivedamage and apoptosis of nerve cells.